Stanford is already down its top running back. Now, the Cardinal will be without its top wideout.

Head coach David Shaw offered a lengthy injury update for the Cardinal on Tuesday ahead of the team’s matchup with Arizona State this week. The most notable piece of info: wide receiver Michael Wilson will miss a “significant portion of time” with an injury suffered in the team’s 16-14 win over Notre Dame.

Edge rusher David Bailey and offensive lineman Jack Leyrer are considered doubtful. Offensive linemen Walter Rouse, Levi Rogers, and Barrett Miller are all considered to be questionable, but Shaw said they were “trending in the right direction.” Levani Damuni is also considered questionable for the matchup.

Wilson and Leyrer were not listed on the team’s depth chart for the Arizona State game. Bailey was given an OR designation with Aeneas DiCosmo and Lance Keneley at the edge rusher spot on the depth chart.

Rouse was listed as the top left tackle with Miller listed as his primary backup.

It’s a big blow to the offense, Wilson’s injury. He leads the team in targets (40), receptions (26), yards (418), and touchdowns (four). The fifth-year senior is also a captain for the Cardinal. Wilson was limited to just four games because of injury in each of the last two seasons.

Earlier this season, Stanford lost running back EJ Smith to a season-ending injury.

Shaw said he feels this year’s team is deeper than past Stanford teams have been. Injuries cultivate depth, and Stanford’s hand has certainly been forced in recent seasons in that regard. That’s particularly true at wideout; last year’s group was decimated by injury.

John Humphreys, Elijah Higgins, and Brycen Tremayne are listed as starters for the upcoming week.

Stanford (2-4, 0-4 Pac-12) hosts Arizona State (2-4, 1-2 Pac-12) at Stanford Stadium Saturday at 1 p.m. PT on the Pac-12 Network.

You can watch Shaw’s weekly presser below: